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A TREATMENT FOR ADULTS WITH TYPE 2 DIABETES MELLITUS, IN ADDITION TO DIET AND EXERCISE

STARTING THE KOMBIGLYZE XR DIALOGUE WITH YOUR PATIENTS

IMPORTANT TALKING POINTS AND RESOURCES FOR YOUR ADULT PATIENTS WITH TYPE 2 DIABETES MELLITUS

Managing patients with type 2 diabetes mellitus requires more than just the right prescription. It also requires ongoing patient discussion and support. This section contains important topics to discuss with patients for whom KOMBIGLYZE XR may be appropriate and links to additional resources for you and your patients.

1

Discuss whether KOMBIGLYZE XR is appropriate for your patients

  • KOMBIGLYZE XR is for adult patients who need greater glycemic control through a combination of saxagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin, a biguanide1
  • Talk to patients about their risk for lactic acidosis. Serious side effects can happen to patients taking KOMBIGLYZE XR. See the Boxed WARNING for KOMBIGLYZE XR
  • Instruct patients to read the Medication Guide carefully before taking KOMBIGLYZE XR and each time they get a refill
  • Contraindicated in patients with severe renal impairment (eGFR below 30 mL/min/1.73 m2)

2

Discuss the convenience of individualized, once-daily dosing

  • The dosage of KOMBIGLYZE XR should be individualized based on the patient’s current regimen, effectiveness, and tolerability. Maximum daily recommended dose is 5 mg saxagliptin and 2000 mg metformin XR that can be taken as two 2.5/1000 mg tablets once a day1
  • Strong CYP3A4/5 inhibitors (eg, ketoconazole): Coadministration with KOMBIGLYZE XR significantly increases saxagliptin concentrations. Recommend limiting saxagliptin dosage to 2.5 mg once daily
  • Assess renal function prior to initiation of KOMBIGLYZE XR and periodically thereafter. If eGFR falls below 45 mL/minute/1.73 m2, assess the benefit risk of continuing therapy and limit dose of the saxagliptin component to 2.5 mg once daily. Discontinue KOMBIGLYZE XR if eGFR falls below 30 mL/minute/1.73 m2
  • KOMBIGLYZE XR should generally be taken once daily with the evening meal with gradual dose titration to reduce the gastrointestinal side effects associated with metformin1

3

Encourage patients to access money-saving* offers and helpful patient support resources

  • Affordability is an important factor for diabetes patients and their health care professionals. Explore money-saving offers for eligible* patients who have been prescribed KOMBIGLYZE XR
  • Share helpful resources, listed below, to provide educational and treatment support for your patients

*Subject to eligibility. Restrictions apply. Not available for government-insured patients.

DOWNLOADABLE RESOURCES

Help reinforce the patient dialogue with these downloadable patient support resources:

DOWNLOADABLE RESOURCES

Help reinforce the patient dialogue with these downloadable patient support resources:

KOMBIGLYZE XR PATIENT BROCHURE —explains how KOMBIGLYZE XR may help lower blood sugar with descriptions of how KOMBIGLYZE XR works in the body, and the results of two clinical studies. It also shows how patients can save money on their prescriptions of KOMBIGLYZE XR, and the support available through the Fit2Me™ program that helps patients design appropriate meal plans and activities that they enjoy

MANAGING YOUR TYPE 2 DIABETES SHEET —diet and lifestyle suggestions to help your patients manage their type 2 diabetes, such as taking a short walk after meals or drinking one less soda per day. Includes descriptions of basic terms such as A1C, and a goal-setting guide

WHAT ARE YOUR NUMBERS TELLING YOU? BROCHURE —descriptions and illustrations to help patients understand type 2 diabetes, and how measurements such as A1C, FPG, and PPG are used to track their blood glucose levels. It also describes other health care specialties that you may recommend such as ophthalmologists, dietitians, and podiatrists

WHAT ARE YOUR NUMBERS TELLING YOU? BROCHURE IN SPANISH —the same brochure described above to give to your Spanish-speaking patients

PATIENT SUPPORT SITES

Help your adult type 2 diabetes patients design their support program, their way.

Fit2Me is:

  • A free, comprehensive online diet and lifestyle support program designed to help you and your patient make diet and lifestyle choices that fit into their type 2 diabetes mellitus treatment plan
  • A comprehensive program built for your patient, using the foods they love, the activities they like to do, and the motivational support they choose

VISIT FIT2ME.COM »

Your patients want to learn about their type 2 diabetes mellitus. You can help them understand.

Health Journey Support is:

  • An online health library to share with your patients, containing videos and printable brochures, including information on type 2 diabetes mellitus
  • A source of educational materials across AstraZeneca therapeutic areas, from diagnosis to treatment and wellness. Helping patients through the health journey every step of the way

VISIT HEALTHJOURNEYSUPPORT.COM »