WARNING FOR KOMBIGLYZE XR: LACTIC ACIDOSIS
US Full Prescribing Information including Boxed WARNING about lactic acidosis, and Medication Guide
Lactic acidosis is a rare, but serious, complication that can occur due to metformin accumulation. The risk increases with conditions such as sepsis, dehydration, excess alcohol intake, hepatic impairment, renal impairment, and acute congestive heart failure.
The onset of lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress.
Laboratory abnormalities include low pH, increased anion gap, and elevated blood lactate.
If acidosis is suspected, KOMBIGLYZE™ XR (saxagliptin and metformin HCl extended-release) should be discontinued and the patient hospitalized immediately. [See Warnings and Precautions]
Click here for Important Safety Information including complete Boxed WARNING about lactic acidosis
A TREATMENT FOR ADULTS WITH TYPE 2 DIABETES MELLITUS, IN ADDITION TO DIET AND EXERCISE
Managing patients with type 2 diabetes mellitus requires more than just the right prescription. It also requires ongoing patient discussion and support. This section contains important topics to discuss with patients for whom KOMBIGLYZE XR may be appropriate and links to additional resources for you and your patients.
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*Subject to eligibility. Restrictions apply. Not available for government-insured patients.
DOWNLOADABLE RESOURCES
Help reinforce the patient dialogue with these downloadable patient support resources:
DOWNLOADABLE RESOURCES
Help reinforce the patient dialogue with these downloadable patient support resources:
KOMBIGLYZE XR PATIENT BROCHURE —explains how KOMBIGLYZE XR may help lower blood sugar with descriptions of how KOMBIGLYZE XR works in the body, and the results of two clinical studies. It also shows how patients can save money on their prescriptions of KOMBIGLYZE XR, and the support available through the Fit2Me™ program that helps patients design appropriate meal plans and activities that they enjoy
MANAGING YOUR TYPE 2 DIABETES SHEET —diet and lifestyle suggestions to help your patients manage their type 2 diabetes, such as taking a short walk after meals or drinking one less soda per day. Includes descriptions of basic terms such as A1C, and a goal-setting guide
WHAT ARE YOUR NUMBERS TELLING YOU? BROCHURE —descriptions and illustrations to help patients understand type 2 diabetes, and how measurements such as A1C, FPG, and PPG are used to track their blood glucose levels. It also describes other health care specialties that you may recommend such as ophthalmologists, dietitians, and podiatrists
WHAT ARE YOUR NUMBERS TELLING YOU? BROCHURE IN SPANISH —the same brochure described above to give to your Spanish-speaking patients
PATIENT SUPPORT SITES
Your patients want to learn about their type 2 diabetes mellitus. You can help them understand.
Health Journey Support is: