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EXPLORE THE KOMBIGLYZE XR MECHANISM OF ACTION

Discover how KOMBIGLYZE XR improves glycemic control by incorporating the mechanism of saxagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, with metformin, a biguanide.

Response of eating and increased production of hormones GLP-1 and GIP incretins in the blood stream

1

THE ROLE OF INCRETINS

IN GLUCOSE HOMEOSTASIS

Eating increases levels of glucose in the body.

In response to increased levels of glucose, the small intestine increases production and release of GLP-1 and GIP incretins into the bloodstream. These hormones contribute to glucose homeostasis.1

1

THE ROLE OF INCRETINS

IN GLUCOSE HOMEOSTASIS

Eating increases levels of glucose in the body.

In response to increased levels of glucose, the small intestine increases production and release of GLP-1 and GIP incretins into the bloodstream. These hormones contribute to glucose homeostasis.

2

THE ROLE OF DPP-4

IN THE LIFESPAN OF INCRETINS

The enzyme DPP-4 begins degrading the GLP-1 and GIP incretins within minutes of their release. Consequently, GLP-1 and GIP are short-lived, disrupting glucose homeostasis.1

2

THE ROLE OF DPP-4

IN THE LIFESPAN OF INCRETINS

The enzyme DPP-4 begins degrading the GLP-1 and GIP incretins within minutes of their release. Consequently, GLP-1 and GIP are short-lived, disrupting glucose homeostasis.

3

HOW KOMBIGLYZE XR WORKS

USING COMBINED ROLES OF SAXAGLIPTIN AND METFORMIN HCL

KOMBIGLYZE XR is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both saxagliptin and metformin is appropriate.1

The saxagliptin component of KOMBIGLYZE XR inhibits DPP-4 enzymes, thereby prolonging the action of naturally secreted incretins GLP-1 and GIP.1

3

HOW KOMBIGLYZE XR WORKS

USING COMBINED ROLES OF SAXAGLIPTIN AND METFORMIN HCL

KOMBIGLYZE XR is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both saxagliptin and metformin is appropriate.

The saxagliptin component of KOMBIGLYZE XR inhibits DPP-4 enzymes, thereby prolonging the action of naturally secreted incretins GLP-1 and GIP.

4

KOMBIGLYZE XR IMPROVES GLYCEMIC CONTROL BY COMBINING 2 COMPLEMENTARY MECHANISMS OF ACTION

SAXAGLIPTIN inhibits DPP-4 enzyme activity, thereby increasing incretin concentrations in the bloodstream, which increases insulin release by pancreatic alpha cells1

METFORMIN improves insulin sensitivity by increasing peripheral glucose uptake and utilization by the muscle cells and fat1

  SAXAGLIPTIN + METFORMIN both decrease hepatic glucose production1

decrease in A1C level due to a decrease in hepatic glucose production

KOMBIGLYZE XR helps to reduce fasting plasma glucose (FPG) and postprandial glucose (PPG) in a glucose-dependent manner, which helps to reduce blood glucose levels and A1C.1

 

CONSIDER KOMBIGLYZE XR

A TREATMENT FOR ADULTS WITH TYPE 2 DIABETES MELLITUS, IN ADDITION TO DIET AND EXERCISE

Give your patients a kickstart with KOMBIGLYZE XR.

EXPLORE A1C DATA »

When individualizing treatment for your patients, hypoglycemia may be a concern: